The hosts are in fine form and own the longest unbeaten record in the division heading into the game. Jose Mourinho's side have picked up 17 of the 21 points available in that time and could go top of the table with all three at the Tottenham Hotspur Stadium.
The visitors will be boosted with the news manager Pep Guardiola has committed his future to the club, putting pen to paper on a new two-year contract extension to put any talk of an exit at the end of the season to bed.
He will be hoping to get the better of old rival Mourinho again having faced off against him with Barcelona as well as City in recent years.
Spurs sit above City in the league at kick-off and could go a long way to silencing doubts over the credibility of their title challenge with a positive result against one of their true rivals for the trophy.
READ MORE: Premier League fixtures this weekend
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Here's everything you need to know:
When is the match?
The game kicks off on Saturday 21 November at the Tottenham Hotspur Stadium.
What time is kick-off?
Kick-off is 5.30pm GMT.
How can I watch it?
The match is being broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD.
Subscribers can also stream the game live via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
Tottenham will be without Matt Doherty after he tested positive for coronavirus while away on international duty with the Republic of Ireland.
Tanguy Ndombele and Erik Lamela could be available, however, after being sidelined in recent weeks.
For the visitors Raheem Sterling was ruled out of England's trio of international matches with a calf injury making him a doubt for Saturday's match.
Nathan Ake was also injured while away with the Netherlands but Sergio Aguero could return after a hamstring injury of his own before the break.
Tottenham XI: Lloris (C), Aurier, Alderweireld, Dier, Reguilon, Hojbjerg, Sissoko, Ndombele, Bergwijn, Son, Kane
Man City XI: Ederson, Walker, Dias, Laporte, Cancelo, Rodrigo, De Bruyne (C), Mahrez, Bernardo, Torres, Jesus
What are the odds?
Tottenham Hotspur: 3/1
Manchester City: 8/11
Both teams have goals in them and while City's defence has looked in improved in recent weeks, the likes of Harry Kane and Son Heung-min are on fire. The home side may have what it takes to win by the odd goal. Tottenham 2-1 Man City