Devin Toner has been promoted to the Ireland team to play England in the Six Nations on Sunday after Iain Henderson was ruled out.
Coach Andy Farrell had initially named an unchanged team for the crunch Twickenham clash, with Ireland joint-top alongside France after winning their beating Scotland and defending champions Wales.
However, the continuity has been disrupted, as family reasons mean Henderson will be unavailable.
Towering lock Toner, who was surprisingly left out of Ireland's Rugby World Cup squad under previous boss Joe Schmidt, comes into the side for his 70th cap.
The change sees Ultan Dillane take Toner's spot among the replacements.