Ralph Hasenhuttl’s side have continued in a positive vein of form since the restart, defeating strugglers Norwich and Watford to climb within reach of the top half of the table.
Pep Guardiola’s side have also returned in terrific style, thrashing newly crowned champions Liverpool after victories over Arsenal, Burnley and Newcastle. That streak was interrupted, though, by an off-colour performance against Chelsea at Stamford Bridge that deposed their reign as champions.
The club are also still waiting nervously on the result of their appeal against a two-year Champions League ban, with their spot in this season’s top four secured.
Here is everything you need to know:
When is it and what time is kick-off?
The match will begin at 7pm at St Mary’s on Sunday 5 July.
How can I watch it online and on TV?
The match will be shown live on BBC One and will be available via BBC Sport and the BBC iPlayer, with coverage beginning at 6.35pm.
Southampton: McCarthy, Walker-Peters, Stephens, Bednarek, Bertrand, Armstrong, Ward-Prowse, Romeu, Redmond, Ings, Adams
Manchester City: Ederson, Cancelo, Garcia, Laporte, Zinchenko, Fernandinho, D Silva, Bernardo, Mahrez, Jesus, Sterling
What are the odds?
Southampton – 8/1
Draw – 4/1
Man City – 1/3