Mauricio Pochettino has confirmed that the South Korean has travelled despite being left in tears after the Andre Gomes injury incident against Everton, while Harry Kane could return after missing that clash with a virus.
Red Star are a dangerous side at home, and beat an off-colour Liverpool during the group stages last season.
They are one point behind Spurs after three Group B games, with Bayern Munich leading the group.
Here is everything you need to know ahead of the fixture.
Mauricio Pochettino has insisted that Son Heung-min is ready to play despite the Andre Gomes incident, while Harry Kane could return after overcoming a virus.
Erik Lamela and Jan Vertonghen remain out, while Hugo Lloris is a long-term absentee. Giovani Lo Celso could start.
Tottenham: Paulo Gazzaniga; Kyle Walker-Peters, Davinson Sanchez, Juan Foyth, Ryan Sessegnon; Eric Dier, Harry Winks; Lucas Moura, Giovani Lo Celso, Dele Alli; Harry Kane.
Red Star Belgrade 15/4
Red Star are a far tougher proposition at home in Serbia and have not lost a domestic game in more than a month. It could be an edgy night in Belgrade, but Tottenham should be able to battle to three points.
2-1 to Tottenham is our prediction.
When is it?
Kick-off is at 8pm GMT on November 6.
How can I watch it?
The match will be aired live on BT Sport 2, with coverage beginning at 7pm.
Subscribers can also watch the game via the BT Sport app, or online via the BT Sport player.