Protein knocks out HIV by starving it of raw materials

Editors' Picks

  • Beckham effect 'pretty significant' on MLS

    Beckham effect 'pretty significant' on MLS

    Beckham effect 'pretty significant' on MLS

    By Mark Lamport-Stokes LOS ANGELES (Reuters) - As Major League Soccer prepares to open its 20th season, the impact made on MLS by former England captain David Beckham during his six years with LA Galaxy is widely viewed as "pretty significant." Though Beckham's time in the U.S. began unpromisingly as he was sidelined by injury and then skipped several Galaxy games to play on loan with AC Milan in Italy, his eventual influence on the sport extended well beyond his performances on the field. …

  • Cisse faces long ban after accepting FA spit charge

    Cisse faces long ban after accepting FA spit charge

    Cisse faces long ban after accepting FA spit charge

    Newcastle United striker Papiss Cisse will face a severe punishment after accepting an FA charge of spitting at Manchester United defender Jonny Evans in Wednesday's Premier League match. "Both ourselves and Papiss agree this kind of behaviour is not acceptable," Newcastle managing director Lee Charnley said in a statement on Thursday. Evans has also been charged for spitting at Cisse but he denies any wrongdoing. …

  • Sarcastic Van Gaal denies United rift with Giggs

    Sarcastic Van Gaal denies United rift with Giggs

    Sarcastic Van Gaal denies United rift with Giggs

    Manchester United manager Louis van Gaal reacted angrily on Thursday to suggestions he had fallen out with assistant Ryan Giggs. "We have a very bad relationship," the Dutchman said with heavy sarcasm when asked about their relationship at a news conference ahead of the FA Cup quarter-final against Arsenal at Old Trafford on Monday. I am not pleased." British media had questioned the relationship between the manager and Giggs after the United great, sitting alongside Van Gaal at Wednesday's …

  • Newcastle United 0-1 Manchester United: Player Ratings

    Newcastle United 0-1 Manchester United: Player Ratings

    Newcastle United 0-1 Manchester United: Player Ratings

    Rating the performances of both Newcastle and Manchester United's performances in the latter's 1-0 win last night. …

  • Manchester United – A graveyard for modern playmakers?

    Manchester United – A graveyard for modern playmakers?

    Manchester United – A graveyard for modern playmakers?

    Manchester United have always been an attacking team, a team that look to go forward given a small chance. However, the last couple of seasons have seen them struggle for creativity, and yet, they haven't found a place in the team for their playmakers - Shinji Kagawa and Juan Mata. …

  • Referee East back in action after wrongful Brown dismissal

    Referee East back in action after wrongful Brown dismissal

    Referee East back in action after wrongful Brown dismissal

    LONDON (Reuters) - Referee Roger East returns to action in the Premier League on Tuesday, a day after the FA ruled he mistakenly dismissed Sunderland defender Wes Brown at Old Trafford on Saturday. East will be the fourth official when Southampton host Crystal Palace, having come in for heavy criticism for sending off former Manchester United defender Brown at his former club at the weekend for a foul on Radamel Falcao. ... …

Washington, Feb 13 (IANS) A protein knocks out the most virulent form of HIV by starving it of the raw materials it needs to reproduce, in order to protect out immune cells, a study reveals.

"The findings may explain why certain anti-HIV drugs used today are more effective under some circumstances and not others," said Baek Kim, study co-author and professor of microbiology and immunology at the University of Rochester Medical Center.

"It also provides new insights on how many other viruses that afflict people operate in the body," Kim was quoted as saying, by the journal Nature Immunology.

A team of researchers from Rochester, Langone Medical Center, several institutions in France, and a graduate student collaborated on the study, said a university statement.

Researchers are excited about its implications for knowledge of other pathogens, such as herpes viruses, which use the same machinery within our cells that HIV does to replicate.

The work centers on a protein known as SAMHD1 (a molecule), which is found in white blood cells known as macrophages, that specialise in destroying invading viruses and in related cells known as dendritic cells.

Last year scientists discovered that the molecule makes it difficult for HIV-1 to infect macrophages. Now they have unravelled how it actually cuts off the raw material supply that HIV needs to create DNA and replicate.

That raw material, dNTP, comprises the building blocks of DNA, and without it, HIV cannot recreate its DNA in our cells. The team found that SAMHD1 destroys most of these building blocks, making it nearly impossible for HIV-1 to replicate itself where SAMHD1 resides - the macrophages.

Instead, HIV-1 uses the macrophage as a safe haven, surviving in patients for years as it dodges the immune system as well as the drugs designed to kill it.

It's thanks largely to its ability to hide out in the body, that HIV is able to survive for decades and ultimately win out against the body's relentless immune assault.

Most Popular Stories

  • Cricket: Gayle force keeps India on toes

    Cricket: Gayle force keeps India on toes

    AFP
    Cricket: Gayle force keeps India on toes

    Perth, Australia, March 4, 2015 (AFP) - Defending champions India will look to continue their recent success against Chris Gayle when they clash with the West Indies in the World Cup at the WACA ground in Perth on Friday. …

  • Indian national arrested for blasphemous Facebook post

    Indian national arrested for blasphemous Facebook post

    IANS
    Indian national arrested for blasphemous Facebook post

    Riyadh, March 5 (IANS) The Indian consulate in Jeddah has confirmed the arrest of an Indian in Saudi Arabia for allegedly posting a blasphemous image of the Kaaba on his Facebook page, media reported Thursday. Consul General B.S. Mubarak on Wednesday confirmed that the Indian national has been jailed for violating the country's cyber laws, the Arab News reported on Thursday. "This happened a month ago in Jeddah and the Saudi law enforcement authorities are currently conducting an …

  • Mayank Gandhi defies AAP diktat, flays Yadav and Bhushan's ouster

    Mayank Gandhi defies AAP diktat, flays Yadav and Bhushan's ouster

    Yahoo India
    Mayank Gandhi defies AAP diktat, flays Yadav and Bhushan's ouster

    Mayank Gandhi confirmed that Kejriwal had said that he would not be able to work as convenor as long as both Yogendra Yadav and Prashant Bhushan were part of the PAC. …

  • After beef ban, Hindu groups force abattoirs to close

    After beef ban, Hindu groups force abattoirs to close

    Reuters
    After beef ban, Hindu groups force abattoirs to close

    By Meenakshi Sharma MUMBAI (Reuters) - Members of a Hindu nationalist group have forced several abattoirs in Maharashtra to shut after a law was passed banning the beef trade there, a leader of the group and a lawyer for meat traders said on Wednesday. The Vishwa Hindu Parishad, or World Hindu Council, a nationalist group linked to Prime Minister Narendra Modi's ruling party, acted after winning a court order to stop the killing of bulls and bullocks. "Members of the VHP came to Deonar …

  • Shoaib Akhtar blasted for mocking '150 year old' Pak squad on Indian comedy show

    ANI

    Karachi, Mar 05 (ANI): Former Pakistani fast bowling great Shoaib Akhtar has reportedly been blasted on Twitter for mocking the national squad in a popular Indian comedy television show. Akhtar appeared with Indian cricketer Harbhajan Singh on a comedy show in India called 'Comedy Nights with Kapil', which is popular in both India and Pakistan. Among other things, Akhtar joked about Pakistani cricket team captains being old, saying that if they add up Misbah-ul Haq's, Younis Khan's and Shahid …