Captain Harry Maguire and Eric Bailly did not travel due to injury, leaving just Victor Lindelof as the only recognised senior centre-back in Paris with Axel Tuanzebe and Luke Shaw partnering him.
Alex Telles gets the nod at full-back for his debut. In Maguire's absence, Bruno Fernandes will wear the captain's armband for the first time - while Paul Pogba has been left on the bench.
Mason Greenwood and Jesse Lingard also did not travel, being left at home with Edinson Cavani who continues to work towards his match fitness.
Anthony Martial is available, and fresh, after being suspended for the win at Newcastle United, and leads the line in front of Marcus Rashford and Fernandes.
Paul Pogba should get the nod to start after sitting out the weekend game, while Alex Telles will be hoping to get the call at left-back.
David de Gea should start but Ole Gunnar Solskjaer could hand a Champions League debut to Dean Henderson.
Man United XI: De Gea; Tuanzebe, Lindelof, Shaw; Wan-Bissaka, Fred, McTominay, Telles; Bruno Fernandes, Martial, Rashford
Subs: Henderson, Pogba, Mata, James, Fosu-Mensah, Ighalo, Pellistri, Matic, Williams, Van de Beek