Another defeat for Ole Gunnar Solskjaer could spell the end of his tenure at United, with the club currently 10th in the Premier League, having won just four of their 14 games this season.
Spurs' resurgence under Mourinho continued with 3-2 victory against Bournemouth last weekend, with Dele Alli spearheading three successive victories since the Portuguese's return to management. Follow live coverage of the game as well as Chelsea's match against Aston Villa below:
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Scott McTominay is expected to make his return from an ankle injury, while Jesse Lingard could start after Juan Mata's disappointing performance against Villa. The game comes too soon for Paul Pogba, though, who Solskjaer confirmed is not yet ready to return.
Harry Winks could replace Tanguy Ndombele in midfield, while Danny Rose could return to counteract United's pace down the flanks.
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Williams; McTominay, Fred; James, Lingard, Rashford; Martial
Tottenham: Gazzaniga; Aurier, Alderweireld, Sanchez, Rose; Dier, Winks; Sissoko, Alli, Son; Kane
When is it?
The match is on Wednesday 4 December.
When does it kick-off?
The match gets underway at 7:30pm.
How can I watch the match?
The match will be available to watch and stream on Amazon Prime.
What are the odds?
Manchester United to win: 13/8
Tottenham to win: 8/5
The match will be frenetic with Mourinho’s former players desperate to stick it to him, while the manager himself will urgently want to get one over United at Old Trafford.
However, the two sides are on such dramatic different planes of momentum at the moment that, although United could start with a renewed vigour and desire, Spurs’ quality and form should ultimately shine through in a hot-blooded encounter.
Manchester United 1-3 Tottenham
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