United are currently top of group H with six points, alongside RB Leipzig who also have two wins from their opening three games.
Istanbul were expected to be the whipping boys of the group but their surprise victory over United in Turkey has given them hope of staying in Europe, and they have three points.
Ole Gunnar Solskjaer says United need “at least 10 points” to qualify for the last 16, so with tougher tests to come this is a crucial fixture to win.
Here is everything you need to know:
Read more: United handed potential Pogba boost
Follow: United vs Istanbul LIVE
When is the game?
Manchester United vs Istanbul Basaksehir is on Tuesday 24 November.
What time is kick-off?
The match kicks off at 8pm GMT.
Is the game on TV?
The match will be shown in the UK on BT Sport 2 and BT Sport Ultimate. BT Sport customers can stream the game online via the BT Sport website and the BT Sport app.
United remain without Phil Jones, Luke Shaw and Jesse Lingard. Paul Pogba was not deemed fit enough to be involved.
De Gea, Wan-Bissaka, Lindelof, Maguire, Telles, van de Beek, Fred, Rashford, Fernandes, Martial, Cavani.
Manchester United 1/4
Istanbul Basaksehir 12/1
Mancheser United will make amends for their shocking defeat in Turkey. United 2-0 Istanbul.