Ole Gunnar Solskjaer's side have only been beaten once in the Premier League at home this season, and could end the weekend in fifth place if other results go their way.
Scott McTominay could be fit to start in midfield, while the three-man defence employed from the start at Sheffield United last weekend seems unlikely to be utilised again.
Dean Smith could select an unchanged team after an impressive performance against Newcastle on Monday, with the Villa manager rewarded with a new contract this week.
Here is everything you need to know ahead of the clash.
Manchester United to win: 40/85
Aston Villa to win: 6/1
Manchester United have largely failed to convince this season but should have enough quality in their ranks to beat an Aston Villa side who have largely struggled away from home this season.
3-1 to Manchester United is our prediction.
Paul Pogba has returned to England but is not yet close to a full return to fitness, but the likely availability of Scott McTominay should solve Ole Gunnar Solskjaer’s midfield questions.
Jota is continuing his recovery from injury for Aston Villa, and this game may come too soon, but Bjorn Engels is available. It is possible that Smith selects an unchanged team after an impressive performance against Newcastle on Monday night.
Man Utd: de Gea, Wan Bissaka, Lindelof, Maguire, Williams, Andreas Pereira, Fred, James, Mata, Rashford, Martial
Aston Villa: Heaton, Guilbert, Konsa, Mings, Targett, McGinn, Douglas Luiz, Hourihane, El Ghazi, Wesley, Grealish
When is it?
The match is on Sunday 30 November.
When does it kick-off?
The match gets underway at 4.30pm GMT.
Can I watch the match?
The match is not being broadcast live in the UK but you can watch highlights on Match of the Day 2 on BBC 1 at 22.30.
We will also have a live blog where you can follow all of the action.