The centre back is suffering from illness and drove away from Carrington after just 15 minutes being assessed by the club’s medical staff.
It means Eric Bailly could be in line for his first start of the season after recovering from a serious knee injury.
Phil Jones is another option - but Lindelof’s absence is a fresh blow to Ole Gunnaer Solskjaer who is already without defenders Marcos Rojo and Axel Tuanzebe.
Man Utd are also threadbare in midfield and attack after injuries to Paul Pogba, Scott McTominay and Marcus Rashford.
Rashford will be out for up to three months after suffering a double stress fracture of the back - but Solskjaer has defended his handling of the England striker, despite admitting the player had complained of discomfort after the win against Burnley on December 28.
The Norwegian said: “He will be out for a while. He’ll get the time he needs to recover.
“He’s not had that injury before. He complained a little bit after Burnley. He felt it the first time, and we managed him as well as we could then.
“Then he had some days off for treatment, taken off in games and suddenly this was a new injury. He didn’t have any injuries before then.
“He wants to get back as quickly and safely as possible and we’ll give him that time. When he feels ready and medically cleared he’ll be back.”
How Man Utd could lineup against Burnley…
Man Utd predicted XI (4-2-3-1): De Gea; Wan-Bissaka, Bailly, Maguire, Williams; Matic, Fred; Greenwood, Pereira, James; Martia