The Argentinian is yet to take part in full training since breaking down in June and has been ruled out of Man City’s opening game against Wolves tonight.
Pep Guardiola had hoped Aguero would be able to take part in the Champions League closing stages last month, but his recovery has taken longer than club medics expected.
City’s manager said: “He still hasn’t had one training session with us.”
It means Brazilian forward Gabriel Jesus leads City’s attack at Molineux as Guardiola’s only like-for-like back up.
Riyad Mahrez has been back in training this week after testing positive for Covid-19 and takes a seat on the bench, but Aymeric Laporte, who also tested positive, is out of the Wolves game along with Ilkay Gundogan, whose own positive test was announced by the club earlier on Monday.
“Riyad came back a few days ago, he’s training,” said Guardiola.
“Today is the first day for Laporte. Riyad is available, but Laporte not yet.”
New signings Nathan Ake and Ferran Torres, who arrived from Bournemouth and Valencia respectively, are both involved on Monday, with Ake starting in defence and Torres on the bench.
Guardiola added: “I see the team in incredible mood. It is a joy to work with them.
"We’ve got good expectations to play good football, get the results they deserve and continue the consistency.”
Wolves XI: Rui Patrício, Boly, Coady (C), Saïss, Traoré, Rúben Neves, João Moutinho, Marçal, Podence, Jiménez, Neto
Subs: Dendoncker, Ruddy, Rúben Vinagre, Fabio Silva, Vitinha, Buur, Kilman
Man City XI: Ederson, Walker, Stones, Ake, Mendy, Rodrigo, Fernandinho (C), De Bruyne, Foden, Sterling, Jesus
Subs: Steffen, Torres, Mahrez, Otamendi, Delap, Doyle, Bernabe