With Jurgen Klopp's side playing first on Saturday, the gap could be as great as 11 points come kick-off.
Pep Guardiola's side have suffered defeats to Norwich, Wolves and Liverpool this season and continue to struggle with their injury-hampered defence.
Meanwhile, Frank Lampard's side are riding a wave of momentum, having won their last six league games.
Here is everything you need to know:
Man City: Guardiola’s defence are severely hampered by injury with Aymeric Laporte and Oleksandr Zinchenko still missing due to injury.
However, there’s hope Ederson will recover in time from a thigh strain.
Bernardo Silva is suspended following his one-match ban for his controversial tweet aimed at teammate Benjamin Mendy.
Chelsea: Christian Pulisic was forced to pull out of international duty with the US due to a hip injury, however, Chelsea are hopeful the winger will still be available.
Ross Barkley should be also be fit to return, while Jorginho returns from suspension.
Ruben Loftus-Cheek and Antonio Rudiger remain longer-term absentees.
Man City: Ederson; Walker. Stones, Fernandinho, Mendy; David Silva, Rodri, De Bruyne; Mahrez, Sterling, Aguero.
Chelsea: Kepa; Azpilicueta, Zouma, Tomori, Emerson; Kovacic, Jorginho, Kante; Mount, Abraham, Pulisic.
When is it?
The match is on Saturday 23 November.
When does it kick-off?
The match gets underway at 5:30pm.
How can I watch the match?
The match will be available to watch and stream on Sky Sports Main Event from 5pm.
What are the odds?
- Man City to win: 4/9
- Draw: 19/5
- Chelsea to win: 5/1
Chelsea are riding a good wave of momentum with their young side more than capable of causing the upset. However, City’s quality should ultimately see them rise to the occasion, knowing they can’t afford to let slip any further ground on Liverpool.
Man City 2-1 Chelsea