Jurgen Klopp's Reds lead the table by 19 points, and can go 22 clear of Manchester City if they beat the Hammers on Merseyside this evening.
The Hammers cannot afford another morale-sapping defeat as they sit in the relegation zone, and David Moyes needs to see an improvement as games begin to run out.
But with Liverpool looking for their 26th win out of 27 games, it will take something special for the Hammers to leave Anfield with anything other than a loss.
Here's how you can follow all of the action tonight...
TV channel: The match will be shown live on Sky Sports' Premier League and Main Event channels, and is available via Now TV with a day pass for £9.99.
Live stream: Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app, with a mobile month pass available for £5.99.
Standard Sport: David Lynch and Giuseppe Muro will be providing expert analysis via our rolling match blog. Clich here to follow the match as it happens.
We may earn commission from some of the links in this article, but we never allow this to influence our content. This revenue helps to fund journalism across The Evening Standard.