Hansi Flick’s defending champions were imperious in the group stage, taking 16 out of a possible 18 points. However, their form has suffered slightly in the Bundesliga , with their lead at the top of the table reduced to just two points. They are also without a number of senior players for the trip, with Thomas Tuchel, Benjamin Pavard and Serge Gnabry all unable to travel.
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Bayern do, of course, remain firm favourites, though, with Robert Lewandowski in spectacular form, scoring 31 goals in 30 appearances already this season.
But Lazio should still provide a stern test, having won seven of their last eight Serie A matches, which has seen the club rise back into the top four despite a poor start to the season.
Here is everything you need to know:
When is it and what time is kick-off?
The match will begin at 8pm UK time at the Stadio Olimpico on Tuesday 23 February.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport and the BT Sport App.
Lazio: Reina; Patric, Acerbi, Musacchio; Lazzari, Milinkovic-Savic, Lucas, Alberto, Marusic; Correa, Immobile
Bayern: Neuer; Sule, Boateng, Alaba, Davies; Kimmich, Goretzka; Sane, Musiala, Coman; Lewandowski
What are the odds?
Lazio - 10/3
Draw - 3/1
Bayern - 8/11