Kaizer Chiefs edged out SuperSport United 1-0 in a 2018 Telkom Knockout Cup quarter-final match which was played at the Moses Mabhida Stadium on Sunday afternoon.
Amakhosi were keen to return to winning ways after losing 2-1 to Soweto rivals Orlando Pirates in a PSL game last weekend.
Giovanni Solinas made only one change to the team that faced Pirates as George Maluleka replaced Siphelele Ntshangase in midfield.
Matsatsantsa were also hoping to return to winning ways after drawing 1-1 with Lamontville Golden Arrows in a league game last weekend.
Richard Boateng replaced Onismor Bhasera in the starting line-up as Kaitano Tembo made only one change to the team that faced Arrows.
Amakhosi were seeking vengeance over Matsatsantsa, who had eliminated them from this year's MTN8 in the quarter-finals.
They dominated the match from the start and SuperSport shot-stopper Ronwen Williams was the busier of the two goalkeepers.
The South Africa international denied Chiefs' veteran forward Bernard Parker twice with some good saves as the visitors kept the hosts at bay.
However, Williams was beaten by Willard Katsande's long-range shot, but the upright came to Matsatsantsa's rescue as Amakhosi pushed for the opening goal.
Amakhosi were then awarded a penalty after Ramahlwe Mphahlele was fouled inside the SuperSport box by Boateng, but Katsande hit the upright from the spot-kick.
The Soweto giants continued to press and they deservedly broke the deadlock when Mphahlele scored with a wonder goal from the edge of the box to make it 1-0 to Chiefs.
The visitors tried to respond with a goal with English hitman James Keene working tirelessly upfront for Matsatsantsa.
However, Chiefs stood firm at the back and they were leading 1-0 at the interval.
SuperSport dominated the opening stages of the second half with Tembo having introduced former Chiefs midfield maestro Reneilwe Letsholonyane.
The experienced midfielder pulled the strings in the middle of the park - playing some forward passes as he looked to unlock the Amakhosi defence.
Keene's header sailed over the crossbar before his Matsatsantsa team-mate Phumlani Ntshangase missed the target with a low shot.
The Tshwane giants, who had scored most of their goals (27.3%) between the 60th minute and 75th minute in the league this season, piled pressure on the Amakhosi backline.
However, Solinas pulled out attack-minded duo Parker and Khama Billiat and he introduced Philani Zulu, and Daniel Cardoso as Chiefs looked to hold on to their slender lead.
Ultimately, Chiefs emerged 1-0 winners over SuperSport after containing the visitors in the latter stages of the game.
As a result, Amakhosi joined Pirates, Baroka FC and Bidvest Wits in the semi-finals.