Amakhosi were brimming with confidence having secured their maiden league win of the season when they thumped Cape Town City 4-1 in the Mother City over the weekend.
Giovanni Solinas made seven changes to the team that faced the Citizens with Venezuelan striker Gustavo Paez among the players who were making their return to the starting line-up.
Ea Lla Koto were desperate for victory having succumbed to a narrow 1-0 defeat to Polokwane City in Limpopo over the weekend.
Luc Eymael made only two changes with promising winger Yusuf Jappie and Congolese midfield maestro Cesaire Gandzie returning to the starting line-up as Stars looked for revenge.
This was the second meeting between Stars and Chiefs this season with the two teams having clashed in the MTN8 Cup quarter-final game. Amakhosi emerged 3-0 winners over Ea Lla Koto in Johannesburg in the first match.
All eyes were on Khama Billiat, who had netted twice during Chiefs' win over City on Saturday, and the Zimbabwean attacker was involved in the opening goal of the match in the 25th minute.
Billiat sent Paez through on goal with an exquisite pass and the latter beat Stars goalkeeper Badre Ali Sangare from a one-on-one situation to make it 1-0 to Chiefs.
Philani Zulu had been rewarded with a place in the Chiefs starting line-up after scoring his first goal for the club against City.
Zulu made it two goals in as many matches as he fired past a hapless Sangare to make it 2-0 to Chiefs following a good move by Solinas' charges in the 34th minute.
The goal did not come as a surprise as Amakhosi had scored the majority of their goals this season (33.3%) within the final 15 minutes of the first half.
Chiefs were deservedly leading 2-0 at the interval having converted their chances.
Belgian tactician Eymael decided to introduce Eleazar Rodgers in the early stages of the second half as Ea Lla Koto looked to score their first goal of the match.
The hosts were hoping that the lanky striker replicates the form which saw him grab a brace as his former side beat Chiefs 2-1 in a league game in January 2016.
Italian mentor Solinas tasked towering defender Booysen with man-marking Rodgers, who is a good header of the ball with Stars playing long balls into the Chiefs box.
Andriamirado 'Dax' Andrianarimanana, who is a central defensive midfielder by trade, was handed his Chiefs debut in the closing stages of the game as the visitors looked to contain Stars.
Chiefs stood firm at the back in the dying minutes of the encounter and they emerged 2-0 winners over Stars.
The convincing win took Amakhosi to third place on the league standings - leapfrogging Orlando Pirates, while Ea Lla Koto remained 15th on the table.