The American and Mexican will come in at the 130 pounds, but both the WBA super featherweight and lightweight titles will be on the line.
Tank has been guided to this point by promoter and mentor Floyd Mayweather Jr, with the pay-per-view event the first of his career.
Santa Cruz, now 32 and seven years Davisâ senior, will hope his work rate will cause his opponent issues, having struggled to put away a determined Yuriorkis Gamboa last time out until the 12th round after flooring the Cuban in the second.
Hereâs everything you need to know about the fight.
When and where is the fight?
The fight will take place at the Alamodome in San Antonio, Texas on 31 October. You can expect the ring walks to take place some time after 3am UK time on Sunday morning.
What TV channel is it on and is there a live stream?
American fans will be able to catch the fight on Showtime Sports in a pay-per-view event.
The fight will cost fans $74.99 in the United States.
The fight will air on Channel 5 in the UK, meaning British fight fans will get it for free, coverage beginning at 2am on Sunday.
Santa Cruz: 4/1
Davis by KO/TKO: 11/10
Davis on points: 5/4
Santa Cruz by KO/TKO: 12/1
Santa Cruz on points: 5/1
Over or Under 10.5 rounds: 5/6