Fungi to fight against cancer?

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    Champions League: Rooney runs riot to seal United group stage berth

    Champions League: Rooney runs riot to seal United group stage berth

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    Van Gaal tips United's Fellaini to succeed up front

    Van Gaal tips United's Fellaini to succeed up front

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  • Rooney runs riot to seal United group stage berth

    Rooney runs riot to seal United group stage berth

    Rooney runs riot to seal United group stage berth

    Manchester United ended their one-year Champions League hiatus in emphatic style when Wayne Rooney struck a hat-trick in a 4-0 destruction of Club Bruges that sent the three-times winners through 7-1 on aggregate on Wednesday. As the playoffs for Europe’s elite club competition reached their climax, Bayer Leverkusen, BATE Borisov, CSKA Moscow and Astana joined United in securing the final places in Thursday’s draw for the lucrative group stage. Astana became the first Kazakh team to qualify …

  • Rooney ends goal drought in style

    Rooney ends goal drought in style

    Rooney ends goal drought in style

    (Reuters) - Manchester United striker Wayne Rooney ended his long goal drought with a hat-trick in their 4-0 Champions League qualifying rout of Club Bruges on Wednesday. The England captain had not scored since a Premier League game against Aston Villa in April, a run of 10 matches and 878 minutes without finding the net. "Obviously, I'm delighted to get the goals but it was a massive game for the club," Rooney told BT Sport. …

  • Dominant Manchester United thrash Club Brugge 4-0 to seal Champions League spot

    Dominant Manchester United thrash Club Brugge 4-0 to seal Champions League spot

    Dominant Manchester United thrash Club Brugge 4-0 to seal Champions League spot

    A hat-trick from Wayne Rooney helped Manchester United defeat Club Brugge 4-0 on the night and 7-1 on aggregate and progress to the Champions League group stage. …

  • Rating Manchester United players in the 4-0 win over Club Brugge

    Rating Manchester United players in the 4-0 win over Club Brugge

    Rating Manchester United players in the 4-0 win over Club Brugge

    Player Ratings out of 10 for the Manchester United starting XI and substitutes …

Washington, Mar 1 (IANS) Inspired by a fungi that secretes a compound to defend their territory, chemists have synthesized and tested dozens of compounds that could act as potential cancer drugs, shows a study.

A few years ago, researchers led by Mohammed Movassaghi, associate professor of chemistry at Massachusetts Institute of Technology (MIT), became the first to chemically synthesize 11,11'-dideoxyverticillin, a highly complex fungal compound that has shown anti-cancer activity in previous studies.

This and related compounds naturally occur in such small amounts that it has been difficult to do a comprehensive study of the relationship between the compound's structure and its activity - research that could aid drug development, Movassaghi said, the journal Chemical Science reports.

"There's a lot of data out there, very exciting data, but one thing we were interested in doing is taking a large panel of these compounds, and for the first time, evaluating them in a uniform manner," Movassaghi said, according to an MIT statement.

In the new study, Movassaghi and colleagues at MIT and the University of Illinois at Urbana-Champaign (UIUC) designed and tested 60 compounds for their ability to kill human cancer cells.

"What was particularly exciting to us was to see, across various cancer cell lines, that some of them are quite potent," said Movassaghi.

Postdoc Nicolas Boyer and graduate student Justin Kim from MIT, Illinois chemistry professor Paul Hergenrother and graduate student Karen Morrison also co-authored the study.