Fungi to fight against cancer?

Editors' Picks

  • Atletico Madrid defender Miranda undergoes medical ahead of move to Inter Milan

    Atletico Madrid defender Miranda undergoes medical ahead of move to Inter Milan

    Atletico Madrid defender Miranda undergoes medical ahead of move to Inter Milan

    Miranda will complete a £10.6m move from Atletico Madrid to Inter Milan subject to clearing the medical …

  • Sergio Ramos has told Real Madrid he wants to leave

    Sergio Ramos has told Real Madrid he wants to leave

    Sergio Ramos has told Real Madrid he wants to leave

    Manchester United have reportedly made £28.5m bid for the Real Madrid defender. …

  • Hiddink steps down as Netherlands coach

    Hiddink steps down as Netherlands coach

    Hiddink steps down as Netherlands coach

    Guus Hiddink has quit as coach of the Netherlands after spending less than one year in his second spell in the job, the Football Association (KNVB) announced on Monday. The 68-year-old hands over to assistant Danny Blind with the Dutch third in their Euro 2016 qualifying group, facing the possibility of a playoff tie to win a spot at next year's championship in France. The much-travelled Hiddink has delivered some mediocre results and been heavily criticised since taking over from Manchester …

  • United make bid for Real defender Ramos - reports

    United make bid for Real defender Ramos - reports

    United make bid for Real defender Ramos - reports

    LONDON (Reuters) - Manchester United have made a 28.6 million pound ($45 million) bid for Real Madrid defender Sergio Ramos, British media reported on Monday. Media reports said the 29-year-old Spain international was keen to move to Old Trafford, despite having two years left on his Real contract. United manager Louis van Gaal is seeking to shore up the Premier League club's defence to help improve on last season's fourth-place finish. United confirmed earlier on Monday that defender Phil …

  • Jones extends Man United contract

    Jones extends Man United contract

    Jones extends Man United contract

    Defender Phil Jones has signed a contract extension with Manchester United to keep him at Old Trafford until at least 2019, the Premier League club said on Monday. The 23-year-old England international joined United from Blackburn Rovers in 2011 for a reported fee of 16.5 million pounds ($26 million). "We are delighted that Phil has signed a new contract," United manager Louis van Gaal told the club's website. …

  • An open letter to David de Gea from a Manchester United fan

    An open letter to David de Gea from a Manchester United fan

    An open letter to David de Gea from a Manchester United fan

    An open letter from a Manchester United fan to David de Gea, asking him to stay at the club and decline a move to Real Madrid. …

Washington, Mar 1 (IANS) Inspired by a fungi that secretes a compound to defend their territory, chemists have synthesized and tested dozens of compounds that could act as potential cancer drugs, shows a study.

A few years ago, researchers led by Mohammed Movassaghi, associate professor of chemistry at Massachusetts Institute of Technology (MIT), became the first to chemically synthesize 11,11'-dideoxyverticillin, a highly complex fungal compound that has shown anti-cancer activity in previous studies.

This and related compounds naturally occur in such small amounts that it has been difficult to do a comprehensive study of the relationship between the compound's structure and its activity - research that could aid drug development, Movassaghi said, the journal Chemical Science reports.

"There's a lot of data out there, very exciting data, but one thing we were interested in doing is taking a large panel of these compounds, and for the first time, evaluating them in a uniform manner," Movassaghi said, according to an MIT statement.

In the new study, Movassaghi and colleagues at MIT and the University of Illinois at Urbana-Champaign (UIUC) designed and tested 60 compounds for their ability to kill human cancer cells.

"What was particularly exciting to us was to see, across various cancer cell lines, that some of them are quite potent," said Movassaghi.

Postdoc Nicolas Boyer and graduate student Justin Kim from MIT, Illinois chemistry professor Paul Hergenrother and graduate student Karen Morrison also co-authored the study.