As countries emerge from latest round of coronavirus lockdowns, this is the future of the COVID-19 pandemic

The New York Times

By now we know that the novel coronavirus will be with us for a rather long time.

"Exactly how long remains to be seen," said Marc Lipsitch, an infectious disease epidemiologist at Harvard's TH Chan School of Public Health. "It's going to be a matter of managing it over months to a couple of years. It's not a matter of getting past the peak, as some people seem to believe."

A single round of social distancing €" closing schools and workplaces, limiting the sizes of gatherings, lockdowns of varying intensities and durations €" will not be sufficient in the long term.

In the interest of managing our expectations and governing ourselves accordingly, it might be helpful, for our pandemic state of mind, to envision this predicament €" existentially, at least €" as a soliton wave: A wave that just keeps rolling and rolling, carrying on under its own power for a great distance.

The Scottish engineer and naval architect John Scott Russell first spotted a soliton in 1834 as it traveled along the Union Canal. He followed on horseback and, as he wrote in his Report on Waves, overtook it rolling along at about eight mph, at 30 feet long and a foot or so in height. "Its height gradually diminished, and after a chase of one or two miles I lost it in the windings of the channel."

The pandemic wave, similarly, will be with us for the foreseeable future before it diminishes. But depending on the location and the policies in place, it will exhibit variegated dimensions and dynamics travelling through time and space.

"There is an analogy between weather forecasting and disease modelling," Lipsitch said. Both, he noted, are simple mathematical descriptions of how a system works: drawing upon physics and chemistry in the case of meteorology; and on behaviour, virology and epidemiology in the case of infectious disease modelling. Of course, he said, "we can't change the weather." But we can change the course of the pandemic €" with our behaviour, by balancing and coordinating psychological, sociological, economic and political factors.

Lipsitch is a co-author of two recent analyses €" one from the Centre for Infectious Disease Research and Policy at the University of Minnesota, the other from the Chan School published in Science €" that describe a variety of shapes the pandemic wave might take in the coming months.

The Minnesota study describes three possible futures:

The first depicts an initial wave of cases €" the current one €" followed by a consistently bumpy ride of peaks and valleys that will gradually diminish over a year or two.

The second supposes that the current wave will be followed by a larger fall peak, or perhaps a winter peak, followed by subsequent smaller waves, similar to what transpired during the 1918-19 flu pandemic.

The third shows an intense spring peak followed by a "slow burn" with less-pronounced ups and downs.

The authors conclude that whichever reality materialises (assuming ongoing mitigation measures, as we await a vaccine), "we must be prepared for at least another 18 to 24 months of significant COVID-19 activity, with hot spots popping up periodically in diverse geographic areas."

In the Science paper, the Harvard team €" infectious-disease epidemiologist Yonatan Grad; his postdoctoral fellow, Stephen Kissler; Lipsitch; his doctoral student, Christine Tedijanto; and their colleague Edward Goldstein €" took a closer look at various possibilities by simulating the transmission dynamics using the latest COVID-19 data and data from related viruses.

The authors conveyed the results in a series of graphs €" composed by Kissler and Tedijanto €" that project a similarly wavy future characterised by peaks and valleys.

One figure from the paper depicts possible scenarios (the details would differ geographically) and shows the trajectory of COVID-19 infections in response to "intermittent social distancing."

Social distancing is turned "on" when the number of COVID-19 cases reaches a certain prevalence in the population €" for instance, 35 cases per 10,000, although the thresholds would be set locally, monitored with widespread testing. It is turned "off" when cases drop to a lower threshold, perhaps five cases per 10,000. Because critical cases that require hospitalisation lag behind the general prevalence, this strategy aims to prevent the health care system from being overwhelmed.

Another iteration shows the effects of seasonality €" a slower spread of the virus during warmer months. Theoretically, seasonal effects allow for larger intervals between periods of social distancing.

This year, however, the seasonal effects will likely be minimal, since a large proportion of the population will still be susceptible to the virus come summer. And there are other unknowns, since the underlying mechanisms of seasonality €" such as temperature, humidity and school schedules €" have been studied for some respiratory infections, like influenza, but not for coronaviruses. So, alas, we cannot depend on seasonality alone to stave off another outbreak over the coming summer months.

Yet another scenario takes into account not only seasonality but also a doubling of the critical-care capacity in hospitals. This, in turn, allows for social distancing to kick in at a higher threshold €" say, at a prevalence of 70 cases per 10,000 €" and for even longer breaks between social distancing periods.

What is clear overall is that a one-time social-distancing effort will not be sufficient to control the epidemic in the long term, and that it will take a long time to reach an acceptable herd-immunity percentage.

"This is because when we are successful in doing social distancing €" so that we don't overwhelm the health care system €" fewer people get the infection, which is exactly the goal," Tedijanto said. "But if infection leads to immunity, successful social distancing also means that more people remain susceptible to the disease. As a result, once we lift the social-distancing measures, the virus will quite possibly spread again as easily as it did before the lockdowns."

So, lacking a vaccine, our pandemic state of mind may persist well into 2021 or 2022 €" which surprised even the experts.

"We anticipated a prolonged period of social distancing would be necessary, but didn't initially realise that it could be this long," Kissler said.

Siobhan Roberts c.2020 The New York Times Company

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