Derulo insisted it is "an incredible piece of art" after it was met with a damning response following its world premiere.
Following the reviews, Derulo, part of a star-studded cast that includes Taylor Swift, James Corden and Idris Elba, told US outlet TMZ they "don't matter".
The singer, who plays Rum Tum Tugger in the film, said it will take viewers to "another dimension".
He said: "Any time you defy what an art form is, any time you defy all rules, there's going to be some push-back, obviously.
"But it's an incredible piece of art done by some of the best people in the world."
Derulo called director Tom Hooper a "class act" and questioned the validity of the reviewers' opinions.
He said: "I am just excited for the people to actually see it because reviewers, I mean, what the hell do they know? Have they made a film ever in their life?"
Reviews arrived on Thursday with the Standard's critic branding it as "nearly as obscene as The Human Centipede".
The Daily Telegraph's Tim Robey gave it zero stars, writing: "Once seen, the only realistic way to fix Cats would be to spay it, or simply pretend it never happened."
The long-awaited big-screen adaption of Lord Lloyd-Webber's popular 1981 musical premiered earlier this week.
Its visual style - employing CGI human-cat hybrids - prompted particularly strong criticism.
There were some positive reviews, though, with the Daily Mail's Brian Viner awarding four stars out of five. He wrote that "eight out of 10 cinemagoers will say that they've enjoyed it, as long as they go along prepared for what they're about to see, which is essentially a feline-themed ballet".
Cats will be released in UK cinemas on December 20.