The Selecao are in a good spot after claiming the Copa America recently.
While the Albiceleste are still experimenting with how to get the best out of Lionel Messi while also remaining resolute at the back.
With so much talent on display, it cannot fail to prove fascinating.
Here's everything you need to know about the game.
When is it?
The match kicks off on Friday 15th November at 5pm (GMT), or 8pm local time.
How can I watch it?
The match will not be shown on UK television but you can watch it on Fanatiz or beIN SPORTS in the United States.
Neymar is out injured, but Brazil have plenty of depth up top. Though their depth at goalkeeper has taken a hit with Ederson out injured.
Aston Villa's Douglas Luiz and Wesley are in the squad and could earn their first international caps.
Mauro Icardi continues to be overlooked, though the heir to his throne in Milan, Lautaro Martinez, continues to prove himself as an option over Sergio Aguero or Paulo Dybala.
Brazil: Alisson; Danilo, Silva, Marquinhos, Sandro; Arthur, Casemiro, Coutinho; Jesus, Firmino, Richarlison
Argentina: Andrada; Foyth, Pezzella, Otamendi, Tagliafico; De Paul, Paredes, Lo Celso; Messi, Aguero, Martinez