The concert will not be attended by an audience and access to the public is prohibited due to coronavirus restrictions in place by the Italian government.
However, fans around the world will be able to watch the concert streamed live from Bocelli’s official YouTube channel from 6pm UK time, 10am PST and 1pm EST.
Bocelli will be accompanied during the pro-bono concert only by the cathedral’s organist, Emanuele Vianelli, who will play one of the world’s largest pipe organs.
Among the pieces performed will be “Ave Maria” and Mascagni’s “Sancta Maria”. The concert will be broadcast here.
Milan’s mayor, Giuseppe Sala, said in a statement: “I am happy Andrea has accepted our invitation. This year, Easter will be very different for all of us.
“The joyous serenity that usually comes with this day, has been greatly troubled by the pandemic we are experiencing. I am sure that the extraordinary voice of Bocelli will be the embrace we are missing these days, a strong, special hug, capable of warming the heart of Milan, Italy and the world.”
Bocelli himself said: “The generous, courageous, proactive Milan and the whole of Italy will be again, and very soon, a winning model, engine of a renaissance that we all hope for.
“It will be a joy to witness it, in the Duomo, during the Easter celebration which evokes the mystery of birth and rebirth.”
See our guide to other cultural “days out” to experience from home each weekend here.