A 1-0 lead obtained in the first leg, courtesy of Alexander Lacazette’s late winner, gives Arsenal breathing space and they will hope an element of new-found resilience will see them through.
Mikel Arteta’s have won three successive matches of late after their 3-2 victory at against Everton on Sunday, while Olympiacos beat domestic rivals PAOK over the weekend.
The victors of this tie will progress to potentially face the likes of Wolves, Inter Milan and Sporting CP in the last 16.
Here’s our prediction for the second leg and everything else you need to know about the game.
What time is Arsenal vs Olympiacos?
The match kicks off at 8pm GMT at the Emirates Stadium.
How can I watch on TV?
The game will be shown live on TV in the UK, and can be watched on BT Sport 3 – coverage starts at 7.30pm.
Can I stream it online?
Yes, BT Sport subscribers will be able to stream the match online via the video player and BT Sport app.
Arsenal: Sead Kolasinac will miss the game after damaging his right shoulder at the weekend. Kieran Tierney is still a few weeks away and new signing Cedric Soares is still out with a knee injury. Meanwhile Calum Chambers is out for the rest of the season.
Olympiacos: Ruben Semedo will miss the game through suspension and Hilal Soudani is side-lined with a long-term injury for the Greeks.
Arsenal: Leno; Bellerin, Mustafi, Luiz, Saka; Guendouzi, Xhaka; Pepe, Willock, Martinelli; Lacazette (4-2-3-1).
Olympiacos: Sa; Elabdellaoui, Cisse, Ba, Tsimikas; Bouchalakis, Guilherme, Camara; Masouras, El-Arabi, Valbuena (4-3-3).
Arsenal 2-0 Olympiacos. The Gunners are already halfway there and have an important away goal to ease the pressure. They’re in good form and their quality should prove to be too much for the Greeks.