The Gunners come into the game with a healthy 1-0 lead from last week’s first leg in Piraeus, courtesy of Alexander Lacazette’s late winner.
After gaining an important away goal, Mikel Arteta’s side will be looking for a positive result to get them over the line and ensure that they are in the draw for the last 16.
It is now three successive victories in a row for Arsenal after their 3-2 victory against Everton on Sunday.
Meanwhile, Olympiacos will be looking to cause an upset in London, and come into the game off the back of a 1-0 win away against title challengers PAOK at the weekend.
Here’s our prediction for the second leg and everything else you need to know about the game.
What time is Arsenal vs Olympiacos?
The match kicks off at 8pm GMT at the Emirates Stadium.
How can I watch on TV?
The game will be shown live on TV in the UK, and can be watched on BT Sport 3 – coverage starts at 7.30pm.
Can I stream it online?
Yes, BT Sport subscribers will be able to stream the match online via the video player and BT Sport app.
Arsenal: Sead Kolasinac will miss the game after damaging his right shoulder at the weekend. Kieran Tierney is still a few weeks away and new signing Cedric Soares is still out with a knee injury. Meanwhile Calum Chambers is out for the rest of the season.
Olympiacos: Ruben Semedo will miss the game through suspension and Hilal Soudani is side-lined with a long-term injury for the Greeks.
Arsenal: Leno; Bellerin, Mustafi, Luiz, Saka; Guendouzi, Xhaka; Pepe, Willock, Martinelli; Lacazette (4-2-3-1).
Olympiacos: Sa; Elabdellaoui, Cisse, Ba, Tsimikas; Bouchalakis, Guilherme, Camara; Masouras, El-Arabi, Valbuena (4-3-3).
Arsenal 2-0 Olympiacos. The Gunners are already halfway there and have an important away goal to ease the pressure. They’re in good form and their quality should prove to be too much for the Greeks.