Washington, September 16 (ANI): Researchers have proved for the first time that it is possible to restore restoring decision-making in people who have reduced capacity due to brain disease or injury with the help of a prosthetic device in non-human primates.
In essence, the scientists from Wake Forest Baptist Medical Center used an electronic prosthetic system to tap into existing circuitry in the brain at the cellular level and record the firing patterns of multiple neurons in the prefrontal cortex, the part of the brain involved in decision-making.
They then "played" that recording back to the same brain area to electrically stimulate decision-based neural activity. Not only did it restore function, in some cases, it also improved it.
"The prosthetic device is like 'flipping a switch' to turn on a decision in real time," Sam Deadwyler, senior author of the study, said.
In the study, the scientists trained five monkeys to match multiple images on a computer screen until they were correct 70 to 75 percent of the time.
First, an image appeared on the screen, which the animals were trained to select using a hand-controlled cursor. The screen then went blank for up to two minutes, followed by the reappearance of two to eight images, including the initial one, on the same screen.
When the monkeys correctly chose the image they were shown first, the electronic prosthetic device recorded the pattern of neural pulses associated with their decision by employing a multi-input multi-output nonlinear (MIMO) mathematical model, developed by researchers at the University of Southern California.
In the next phase of the study, a drug known to disrupt cognitive activity, cocaine, was administered to the animals to simulate brain injury. When the animals repeated the image-selection task, their decision-making ability decreased 13 percent from normal.
However, during these "drug sessions," the MIMO prosthesis detected when the animals were likely to choose the wrong image and played back the previously recorded "correct" neural patterns for the task.
According to the study findings, the MIMO device was exceedingly effective in restoring the cocaine-impaired decision-making ability to an improved level of 10 percent above normal, even when the drug was still present and active.
"The basis for why the MIMO prosthesis was effective in improving performance was because we specifically programmed the model to recognize neural patterns that occurred when the animals correctly performed the behavioural task in real time, which is a unique feature of this particular device," Robert E. Hampson, lead author of the study, said.
"Based on the findings of this study, we hope in the future to develop an implantable neuroprosthesis that could help people recover from cognitive deficiencies due to brain injuries," Hampson added.
The study has been published in the Journal of Neural Engineering. (ANI)